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"Its growth depends heavily on a polyphenol- and fiber-rich diet, because without that environment, it doesn't thrive." In other words, if you decide to try it, make sure to eat plenty of fiber- and polyphenol-rich foods

Foods that are difficult to digest, high in fat, or excessively rich may exacerbate gastrointestinal side effects such as nausea, bloating, and abdominal discomfort

In controlled clinical studies as both monotherapy and combination therapy with metformin, pioglitazone, or rosiglitazone and metformin, the overall incidence of adverse reactions, hypoglycemia, and discontinuation of therapy due to clinical adverse reactions with JANUVIA were similar to placebo