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Aoe S, Toba Y, Yamamura J, et al

Although, this effect may also be explained by extinction bursting as the session in which animals received saline (i.v.) was also the first session in which the animals did not receive fentanyl (i.v.)

However the same paracetamol result in a blood sample taken 12 hours after an overdose indicates that without antidote (N-acetylcysteine) treatment, severe, possibly fatal liver damage can be expected

However, NAC has been shown to restore glutathione levels in cases such as acetaminophen overdose where an acute depletion of glutathione is observed [17]