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Thats because having a higher proportion of body fat correlates with the release of more pro-inflammatory cytokines, an attendant decrease in immune function, and potentially increased wound tension from underlying adipose tissue, among other things.7 23 22 Age: Older people tend to have more inflammatory molecules, possibly stemming from elevated levels of reactive oxygen species, which in turn can prolong wound-healing time.24 Theyre also likely to have weakened immune systems, which reduces the ability to fight off infections as well as to heal wounds.25 Other risk factors also contribute to the health conditions that KPV can help treat (e.g., poor nutrition, poor sleep, and smoking), but theyre more feasibly reversible with other interventions
J Biol Chem 244(22):60496055
This principle applies broadly across all semaglutide side effects but has particular relevance for allodynia given its strong dose-response relationship
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