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Nutrition Reviews, 69 (5), 245-258

In the OASIS 4 trial, 7% of participants discontinued treatment due to side effectscomparable to rates seen with injectable formulations

TL;DR GLP-1 microdosing involves taking significantly lower doses of medications like semaglutide (0.05-0.25mg weekly) compared to standard therapeutic doses (0.25-2.4mg)

These medications (including semaglutide, dulaglutide, and liraglutide) are typically considered when: Metformin and other oral medications have not achieved adequate glycaemic control The patient has a BMI 35 kg/m (or lower thresholds, typically by around 2.5 kg/m, for people of certain ethnic backgrounds including South Asian) Weight loss would benefit other obesity-related comorbidities Insulin therapy is being considered but would have significant occupational implications or weight gain is a concern Continuation criteria apply: for example, treatment should reduce HbA1c by at least 11 mmol/mol (1.0%) and weight by at least 3% at 6 months to be continued