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One study has shown that a factor V level less than 10% of normal indicated a poor prognosis (91% mortality), whereas a ratio of factor VIII to factor V of less than 30 indicated a good prognosis (100% survival).[50] The respiratory formulation can also be diluted and filter sterilized by a hospital pharmacist for IV use

However, in patients over 65, those with a history of prediabetes/diabetes, anyone with a cardiovascular disease, and anyone who has been severely overweight should expect to stay on medication forever due to the significant reduction in disability and death

This phenomenon has considerably strained existing manufacturing capacity, leading to weeks of wait time for some patients requiring refills