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These limitations dont invalidate the positive safety findings but do suggest that comprehensive medical supervision remains appropriate for anyone using AOD-9604, particularly for off-label applications or extended treatment periods

Nicotinamide N-oxidation by CYP2E1 in human liver microsomes

Nat Rev Neurosci 9:182194 Boehme M, Van de Wouw M, Van Sandhu K et al (2018) Targeting the gut microbiome to reverse microglia activation and stress-induced immune priming in ageing