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528 shipments of tirzepatide, with 37 (7%) tied to unregistered facilities

Hayes MR, Skibicka KP, Grill HJ

While traditional therapies such as positive airway pressure (PAP) devices are effective in treating OSA and alleviating daytime symptoms, they are often not well tolerated and have limited impact on long-term cardiovascular outcomes

Validation studies of local environmental changes in Ca 2+ and pH within astrocytes in the hippocampus of animals with epilepsy revealed that all cellular enzyme responses are affected by Ca 2+ and pH and that controlling astrocyte pH and/or Ca 2+ may be a new target for epilepsy therapy or the prevention of epilepsy-related adverse events (61)