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Stress: Chronic physical or emotional stress can significantly reduce glutathione levels

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Drug-induced acute liver failure is a fatal disease thats caused by the toxic metabolite N-acetyl-p-benzoquinone-imine that leads to glutathione depletion

Homozygous L2HGDH mutations in germline transmission cause a disease named 2-hydroxyglutaric aciduria (L-2-HGA) 92