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These conditions share common characteristics: persistent low-grade inflammation, incomplete previous healing, and tissue function that has adapted to a suboptimal state

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Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL (1997) Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

I have Interstitial Cystitis and decided to try the O-Shot with targeted injections to my outer urethral area where constant burning has been a symptom for 20+ years