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Furthermore, salicylate-induced tinnitus does not appear to require microglial activation, as minocycline-mediated microglial suppression fails to block tinnitus behavior in this model (Perin et al., 2015)

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For instance, in a xenograft model of colorectal cancer, a pro-angiogenic monocyte subset was identified, defined by the expression of both CD14 and CD16 and the secretion of MMP-9, which exerted tumor-promoting functions (98)

It should help you understand what is driving the trend