B 9 , 135160 (1991)
(8)Fmoc-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin (8) Preparation of Fmoc-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin (7)Fmoc-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin(20DMF)5203DMF3DMF2Fmoc-Pro-OH0.8gDIEA0.4mlTBTU0.56gHOBT0.2gDMF10ml 1.53DMF3DMF2Fmoc-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin In the Fmoc-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin of step (7), add decapping reagent (DMF solution of 20% piperidine), react at room temperature for 5 minutes, pump Dry, re-add the capping agent and react at room temperature for 20 minutes, wash with isopropanol for 3 times, DMF for 3 times, re-distilled DMF for 2 times, drain, add Fmoc-Pro-OH0.8g, DIEA0.4ml, TBTU0 .56g, HOBT0.2g, DMF10ml, reacted at room temperature for 1.5 hours, dried with a vacuum pump, washed 3 times with isopropanol, washed 3 times with DMF, washed 2 times with re-distilled DMF, and dried to obtain Fmoc-Pro-Ala- Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin
[7] There may also be burning or the formation of large, painful cracks when the lips are stretched
And it's just one of the many essential nutrients that keep our body running smoothly
