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Additionally, the Hevin-regulated neurexin-related mechanisms were further enhanced by the discovery of the secreted protein acidic and rich in cysteine (SPARC), which is reciprocally antagonistic to neurexins binding, and MAM domain-containing GPI anchor (MDGA), which is reciprocally antagonistic to neuroligins binding in the neurexins-neuroligins transsynaptic complex [91]

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The continuous evolution of research tools and methodologies, including advancements in analytical techniques and data science, will undoubtedly shed more light on the intricate mechanisms governing peptide action and the necessity of cycling

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