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Considering the small volume (~150 L/cm 2 ) of interstitial fluid in skin [31], locally delivered GSH by HA MN patches (1.6 mg GSH/1 cm 2 MN patch) could act as an antioxidant agent during the MN dissolution process

GLP-1 is one of a pair of incretins (the other being GIPglucose-dependent insulinotropic peptide) that developed in our evolution as modern humans to sense and respond appropriately to incoming dietary fuels and nutrients

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Complete blood count results were normal at the referring hospital, whereas serum biochemical examinations showed a slight increase in alkaline phosphatase (160 U/L, reference range: 089 U/L) and blood urea nitrogen (36.0 mg/dL, reference range: 9.229.2 mg/dL) levels