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Tirzepatide is administered as a once-weekly subcutaneous injection, with a recommended starting dose of 2.5 mg once weekly for 4 weeks, then increasing by 2.5 mg every 4 weeks until the target dose (up to 15 mg) is reached
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Because the enlarging recurrent MPNST was adjacent to the brachial plexus and the subclavian artery (Fig
The implications are significant: Repurposing an inexpensive, widely available drug Targeting the intersection of inflammasome activation, TP53 dysfunction, and neoplastic risk Potential relevance for disorders ranging from CAPS and histiocytosis to MDS and beyond We urgently need more translational work on this underappreciated molecule
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