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The difference reflects population: TRIUMPH-4's osteoarthritis cohort was older and more comorbid

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As demonstrated for the DOR (see below), agonist-induced MOR phosphorylation is carried out hierarchically with first of all the S375, considered as the major phosphorylation site, followed by T370 (El Kouhen et al., 2001)

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130 Taken together, the AT 4 receptor was suggested to mediate renal NO and/or prostaglandin-dependent vasodilation

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