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These restrictions and warnings demonstrate the FDAs stringent consideration of patient safety in the drug approval process.108 In March 2015, the FDA required a black box warning on Tanzeum due to the observed risk of thyroid C-cell tumors in animals, although it is unclear if this effect also occurs in humans.108 Later, the FDA added a warning about the risk of anaphylactic shock to the medications label

They are injected into fatty tissue in the body and often contain phentermine as well as vitamin B12

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