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JCI The magnitude of hepatic fat reduction documented in this trial substantially exceeds outcomes documented for GLP-1 mono-agonist approaches in comparable MASLD populations, providing direct investigational evidence that GCGR co-activation contributes hepatic fat clearance beyond what GLP-1 agonism alone achieves

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A total of 85 healthy women, aged 4365 years old, were randomly assigned to the collagen group ( n = 42), which received supplementation of 5 g daily, or the placebo group ( n = 43) for 12 weeks