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Patrick Zakka, Cardiology Fellow, UCLA HOUSE JONES FACULTY Dr

Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms

In SUSTAIN 6a 2-year placebo-controlled trial investigating cardiovascular outcomessemaglutide led to a significant 26.0% reduction in risk of the primary outcome (a composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke) versus placebo [29]

Second-generation oral semaglutide, whose bioavailability and safety have been significantly improved by the application of new excipients and formulation optimization, but its gastrointestinal side effects are still obvious (Nielsen et al., 2025)