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Clinical Evidence and Real-World Efficacy in Adolescent Populations Published clinical trials for adolescent GLP-1 therapy show meaningful weight reductions over 68 weeks of treatment

Key differences: Doses are a small fraction of male TRT doses The goal is restoration to female physiologic ranges , not optimization Therapy is introduced conservatively and adjusted gradually Clinical guidance from the International Society for the Study of Womens Sexual Health (ISSWSH) supports testosterone therapy for selected women with distressing symptoms when used appropriately and monitored

reported full-year worldwide revenue of about $65 billion in 2025, with Keytruda (pembrolizumab)/Keytruda Qlex (pembrolizumab and berahyaluronidase alfa-pmph) sales amounting to roughly $31.7 billion and continuing to be the companys dominant growth engine, alongside contributions from pulmonary arterial hypertension (PAH) drug Winrevair (sotatercept-csrk), pneumonia vaccine Capvaxive (neumococcal 21-valent conjugate vaccine) and animal health products