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In the obese state, adipose tissue undergoes macrophage infiltration and increased secretion of pro-inflammatory cytokines (such as TNF- and IL-6), which suppress BCAA metabolic enzyme expression and activity through multiple mechanisms ( 2.3.3 BCAA accumulation due to mitochondrial dysfunction A complex reciprocal relationship exists between mitochondrial dysfunction and BCAA accumulation

[DOI] [PMC free article] [PubMed] [Google Scholar] Noctor G, Arisi A-CM, Jouanin L, Kunert KJ, Rennenberg H, Foyer CH

The MOTS-c 5-amino-1MQ stack works through different mechanismsAMPK activation and NNMT inhibitionthat increase energy expenditure and fat oxidation without primarily targeting appetite

This usually happens during dose escalation and often settles as the body adjusts