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This condition primarily arises from an imbalance between muscle protein synthesis and degradation, alongside reduced force-generating capacity, often secondary to neuropathy, myofibrillar disruption, sarcoplasmic reticulum (SR) impairment, altered excitability and mitochondrial dysfunction (68)

Additionally, both studies reported that combining SGLT2is with other therapies (metformin or GLP-1 RAs) enhances efficacy, with the published study highlighting benefits in metabolic parameters with SGLT2i-GLP1RA combinations and our study further demonstrating superior reductions in fat mass and triglycerides with this combination

HCV is an RNA virus and its genetic diversity is constantly evolving due to rapid globalization, which ultimately results in varying therapeutic response in different geographical regions

95%CI, 0.03 to 0.002)