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Tatem AJ, Beilan J, Kovac JR, Lipshultz LI

GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration BioMed Research International GHK-Cu modulates expression of 4,000+ human genes, resetting gene expression patterns of damaged tissues toward health affecting antioxidant, anti-inflammatory, stem cell, and DNA repair pathways

Triggers of elevated ceramide levels comprise hyperosmotic shock [122], secreted sphingomyelinases (SMases) during inflammation [125], sepsis [126] or severe coronavirus disease 2019 (COVID-19) [127], Clostridium perfringens epsilon toxin [128], and platelet-activating factor [129]

Lu, S.C., et al., Insulin and Glucocorticoid Dependence of Hepatic Gamma-Glutamylcysteine Synthetase and Glutathione Synthesis in the Rat Studies in Cultured-Hepatocytes and Invivo