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(Previously, Ozempic was being used for weight loss but had only been approved for diabetes.) In the years following approval, a growing number of household names from Oprah to Elon Musk spoke publicly about their positive experiences using GLP-1s for weight loss
Therefore, reducing fat deposition through GIP receptor antagonism still hold promising therapeutic potential supported by animal models and the fact that individuals with loss-of-function GIPR genetic variants have a lower body mass index (BMI) (39, 9799)
In one study of people new to antipsychotics, those taking metformin saw significantly reduced weight gain, lower BMI , and improved insulin sensitivity
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