Participant selection will be based on the inclusion and exclusion criteria described below
From Day 17 onward, liver organoids were matured in Leibovitz L15 medium supplemented with Dihexa (100 nM), Dexamethasone (100 nM), Hydrocortisone (10 M), Sodium L-ascorbate (50 g/mL), Insulin-transferrin-selenium (0.58%), FBS (8.3%), Glutamax, and BME
In contrast, baseline HbA1c and external eating scores were independently associated with greater reductions in body weight at 12 months ( Table 4 )
Compounds such as resveratrol, curcumin, quercetin, EGCG, berberine, baicalein, polydatin, and phlorizin activate AMPK-SIRT1/PGC-1 and PI3K-Akt pathways, enhance mitochondrial biogenesis and bioenergetics, suppress NF-B/NLRP3 driven neuroinflammation, reduce ROS production, and improve insulin responsiveness