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The cost of re-running a compromised experiment dwarfs the price difference between verified and unverified material

As indicated in Figure 3, positive feedback loops connecting high-calorie/fat meals, overweight/obesity, mitochondrial OxS, skeletal muscle insulin resistance, increased glycemia, and systemic OxS are likely at play in T2D

As a result, since 2008, the FDA has required all new drugs for glycemic control in T2DM patients to demonstrate cardiovascular safety