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Several lines of evidence suggest that the potential roles of LG directly act on human liver cells in vitro to reduce steatosis by decreasing the level of DNL and increasing the fatty acid oxidation (132134)
A meta-analysis of 5 RCTs 42,43,44,45,46 comprising 7,732 adults with T2DM did not observe any effect on cognition, as measured via mini-mental state examination (MMSE) or Montreal cognitive assessment (MoCA), of GLP-1RAs over several months compared with the baseline 38
Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial
Methods Ethics This research complied with all relevant ethical regulations and was approved and overseen by the following ethics review boards
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