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Leflunomide and teriflunomide: altering the metabolism of pyrimidines for the treatment of autoimmune diseases

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The median age of the SCD group was 64 (IQR: 8) years and 66 (8.8) years for the MCI group, which was significantly younger than the HC group (74 4 years) ( p 1 H-MRS and Pittsburgh Compound-B PET

Functioning as a transcription factor, TP53 orchestrates intrinsic apoptosis by dampening the presence of survival proteins such as MCL1, MYC, and BCL2, while elevating pro-apoptotic genes such as BAX in colorectal cancer cells [121, 122]