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For years, there was a widespread belief that the generic was not truly equivalent, and even Quebec's public drug plan, RAMQ, allowed an exception, declining to apply its lowest-cost-alternative policy to Concerta despite generics being available

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These include decreased systemic inflammatory cytokines (TNF-, IL-1, and IL-6), reduced thyroid-infiltrating inflammatory cells through PI3K-Akt pathway modulation, improved metabolic function, and reduced oxidative damage through increased antioxidant capacity [185,186,187]