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[] Early intervention, particularly through intensive glucose control, has long-term benefits for patients with diabetes, a phenomenon known as the legacy effect

MET activation is thus involved in brain plasticity, as suggested by the fact that HGF administration on hippocampal slices enhances the phosphorylation of the glutamatergic NMDA receptor subunit GluN1, augments the NMDA-mediated currents, and increases the amplitude of long-term potentiation (LTP) induced by elevated neuronal activity (Kato et al., 2012)

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Wang Y, Wang Z,Liu M, Chen C, Wang S, Yu L, Yu M