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For people living with obesity and MASH, at present, the authors recommend the use of tirzepatide as first line treatment, but note the Phase III ESSENCE trial, not included in the present algorithm because it was published after January, 2025, showed that semaglutide was associated with a significant improvement in MASH and liver fibrosis similar to tirzepatide

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While primarily studied in animal models, emerging clinical data and its use in compounding pharmacies highlight its promise for conditions ranging from musculoskeletal injuries to gastrointestinal disorders