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Eager to investigate its relationship with hypoglycaemia, in 1958 Marks managed to get some of the newly isolated hormone from Mary Root, the first woman to gain a prominent scientific position at Eli Lilly

The activation of GLP-1 and GIP hormones helps regulate insulin and sugar metabolism while signaling satiety to the brain, which decreases the desire for food

doi: 10.1093/hmg/9.8.1245 100

A broader composite including cardiovascular death, myocardial infarction, stroke, or coronary revascularization was significantly lower with tirzepatide (16.5% vs 18.5), showing reduction of overall atherosclerotic events beyond the narrower MACE definition