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Severe inflammatory bowel disease including active Crohn's disease or ulcerative colitis, and gastroparesis a condition that causes delayed stomach emptying are conditions that typically preclude GLP-1 treatment because the medications further slow gastric emptying

Despite achieving pharmacokinetic objectives in its dose-optimization studies, a safety concern arose when a participant in one of the studies experienced potential drug-induced liver injury, prompting Pfizer to halt development

In general, antioxidant mucoactive medicines play an important role in chronic airway disease, including but not limited to airway mucus clearance, reduced acute exacerbation and improved pulmonary function

In a mouse model of Rett syndrome, DNAC intravenous specifically localized in microglia of diseased brains (but not in healthy tissue) and delivered NAC intracellularly