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DMF induces the expression of L-2-hydroxyglutarate dehydrogenase (L2HGDH) to downregulate L-2-hydroxyglutarate (L2HG) and increase global and locus-specific DNA hydroxymethylation levels

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B12 is water-soluble, meaning excess amounts are eliminated through urine, so the risk of toxicity is very low

However, with traditional vitamins the digestive system acts by dissolving the supplement to free the nutrient, destroying a part of it in the process, and leaving only a small portion of the bioavailable nutrient, as many studies on traditional vitamins indicate