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If continued consumption outpaces metabolic capacity, causing an increase in BAC levels above 0.31-0.45 percent, life-threatening conditions like alcohol poisoning may occur

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin

Thus, it seems that DSIP may indeed play a role in altering physiology in preparation of the body for sleep, as some of it effects occur before neurological and behavioral signs of sleep