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Post-marketing surveillance data from tirzepatide use over several years shows that while nausea and constipation are common early side effects, they are generally mild to moderate and diminish within 48 weeks

doi: 10.1016/j.bbrc.2012.07.140 88 LiuSLiuSWangXZhouJCaoYWangFet al

12, 30 Moreover, a meta-analysis demonstrated a mean 12% (727 kJ) reduction in energy intake during test meals performed during native GLP-1 infusion in participants with and without T2DM