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Activation of AMPK Pathway: MOTS-c modulates the folate and methionine cycles, increasing intracellular levels of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), a potent activator of AMP-activated protein kinase (AMPK)

Radiation alters the surrounding mesenchymal and immune microenvironment, reducing the supply of factors essential for ISC survival and repair, such as R-spondin, epidermal growth factor (EGF) and fibroblast growth factor (FGF) 36