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Using hydroxyl-containing drugsincluding (+)-camptothecin (CPT), SN38, gemcitabine (Gem), and paclitaxel (PTX)we conducted in vitro kinetic assays to assess the reactivity of corresponding prodrugs (S-CPT, S1-SN38, S2-SN38, S1-Gem, S-PTX

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The melanocortin system: POMC and endogenous ligands All endogenous melanocortin ligands derive from a single precursor, proopiomelanocortin (POMC) , a 241-amino acid polypeptide encoded by the POMC gene on chromosome 2p23.3