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The needle insertion registers as a brief pinch

Potential consequences of cold injection include: Enhanced pain perception Cold liquid may stimulate additional nerve receptors, potentially causing more discomfort during injection Possible injection site reactions Some patients report more noticeable redness or tenderness at the injection site with cold administration From a clinical efficacy standpoint , there is no evidence that injecting cold Trulicity significantly compromises its therapeutic effect

PMID: 9 CunninghamPSJacksonCChakrabortyACainJDurringtonHJBlaikleyJF