zepbound vs glp-1 semaglutide and tirzepatide vs. Semaglutide: What You Should Know Wegovy: Tirzepatide vs – GLP-1 for Prevention: Using Drugs

This analysis supports the hypothesis that nausea suppression by GIPR agonism (57, 65, 69) contributes to the better tolerability profile of tirzepatide (15 mg) at doses 6.25x higher than semaglutide (2.4 mg)

doi: 10.1093/jmammal/gyx147 8 DattaS

There was no effect of L-carnitine on other serum lipids (i.e., total and HDL-cholesterol, triglycerides) and anemia-related indicators (i.e., hemoglobin concentration, hematocrit, albumin, and required dose of recombinant erythropoietin) (73)

So on the maintenance side, you were fighting this kind of metabolic adaptation, this biological imperative that your body is trying to get back to its settling point