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Importantly, some of these studies showed that the loss of MOR function after chronic opioid treatment was selective because there was no change in the sensitivity to agonists at other GPCRs known to couple to the same effectors (Christie et al., 1987

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However, when ROS and RNS levels become dysregulated, they can cause oxidative damage to lipids, proteins, and DNA, triggering inflammation, impairing synaptic function, and ultimately contributing to neuronal degeneration [368]