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doi: 10.1104/pp.99.4.1597 5 BrzezowskiP.RichterA

Once you stop taking them, symptoms like insulin resistance and weight gain often come back

The combined effect creates a metabolic state where appetite is significantly reduced, gastric emptying is slowed (meaning food stays in the stomach longer and meals feel more satisfying), insulin dynamics are optimized for fat mobilization rather than fat storage, and resting energy expenditure is elevated through glucagon-mediated thermogenesis

An athlete who once had to manage their weight through meticulous attention to diet, training load, and nutritional periodisation can now achieve a comparable or superior result by injecting themselves once a week