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10 and 11).30 The histological findings, in summary, would be an increased number of melanocytes with atypia (both as individual cells and in nests), pagetoid infiltration, and neoplastic infiltration of the dermis, which distinguishes the invasive form from the in situ form.18,34,35 Recent articles report the possibility of a preliminary assessment through nail clipping and histopathological examination, by observing isolated atypical melanocytes in the nail plate.39 Bowen's disease Bowens disease is the most common malignant tumor of the nail apparatus

Conclusion: The gut microbiota represents a critical hub connecting gastrointestinal and mental health

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