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In light of the agreement, Novo Nordisk said it was withdrawing the patent infringement lawsuit "while reserving the right to refile." Novo ended a similar agreement last year over concerns about compounded drug marketing and sales.

On the other hand, administration of tirzepatide at a dose of 70 nmol/kg/day, resulted in a significant weight loss associated with shorter femur compared to saline-treated diabetic mice, but no evident alterations of bone microarchitecture or strength [69]

A proper brain insulin action has been shown to improve mood and counteract cognitive dysfunction in dementia (215)

The normality assumptions of models were visually checked where appropriate