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However, under conditions of oxidative damage, Nrf2 ceases to be ubiquitinated and degraded, translocating to the nucleus to activate the transcription of numerous genes related to antioxidant defense [66]

147 In addition, the decrease in mitochondrial membrane potential, the gradual increase in intracellular calcium ion levels, and cellular mitochondrial dysfunction occurred with the increasing doses of delphinidin treatment, ultimately led to endometrial cell apoptosis

Ameliorative effect of Acanathopanax senticosus polysaccharides on depressive behavior in rats by regulating PI3K/Akt/mTOR pathway

Eur Neuropsychopharmacol 2011