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Numerous studies have documented the use of NDBs in biomedical devices, including drug delivery systems, contact lenses, and injectable cement, where they exhibit potent antibacterial activity and biocompatibility (Pahlevanzadeh et al., 2022

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The brain regions involved include the hypothalamus, hippocampus, and brainstem, which express GLP-1 receptors

These include: Nausea (the most common complaint, particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite These effects are generally dose-dependent and tend to be most pronounced during the initial weeks of treatment or following a dose increase