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Broadly, studies suggest GLP-1RAs exert their neuroprotective effects in the retina by mediating reduced glutamate excitotoxicity, decreased neuroinflammation, prevention of retinal ganglion cell (RGC) loss, promotion of vascular integrity, promotion of an anti-oxidative environment, and maintenance of glial cells (i.e

Furthermore, blast exposure, a common cause of acoustic trauma and tinnitus, has been associated with altered DNA methylation patterns in peripheral blood, supporting the concept that environmental insults induce lasting epigenetic footprints relevant to tinnitus pathophysiology (Wang et al., 2020)

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