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Aksoy et al (100a) report that "prophylactic" thyroid hormone treatment is associated after 15 months with a decrease in thyroid size and in thyroid antibody levels
Considering dose splitting Some practitioners and patients have explored splitting the weekly dose into two smaller injections given 3 to 4 days apart
For weight management, specific criteria apply as outlined in relevant NICE technology appraisals (such as TA875 for semaglutide 2.4mg), generally requiring a BMI 35 kg/m (or 30 kg/m with weight-related comorbidities), with lower thresholds (typically 2.5 kg/m lower) for people from certain ethnic groups, and treatment within specialist weight management services
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