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Comparison to Other Routes Intravenous: 100% bioavailability (by definitionthe full dose enters circulation) Subcutaneous: Likely 6090% bioavailability (depends on absorption rate) Oral: ~38% systemic bioavailability This is why some researchers hypothetically prefer injected routeshigher bioavailability means lower nominal doses are needed

But the arrival of oral GLP-1s including Foundayo, Eli Lillys newly approved orforglipron pill, and oral versions of Wegovy from Novo Nordisk could dramatically extend the lifespan of appetite suppression

Treatment discontinuation due to adverse events occurred in approximately 5-10% of orforglipron-treated participants

doi: 10.21037/jgo.2018.04.07 240 TrapaniKMBoghossianLJ