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As an upstream event of ferroptosis, autophagy activation can induce ferroptosis through different mechanisms, including NCOA4-mediated ferritin autophagy [95], RAB7A-mediated lipid autophagy [96], ARNTL-mediated biological clock protein autophagy [97], and BECN1-mediated System X c inhibition [64]

In a medically supervised, quality-controlled context with appropriate screening and protocol design, it is generally viewed as a reasonable regenerative strategy and is commonly reported as well tolerated

In WT mice, among the genes examined, Fads1 (involved in lipogenesis) was found to be up-regulated by EtOH and Acox1 (catalyzes the first step of peroxisomal FA oxidation) was repressed (Fig

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