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2021;44(Suppl 1):S73S84

The actual mechanism behind the KES is still under debate, but is most likely related to the dynamic of ion channels, especially sodium channels (Yoshida et al

Acta Physiol (Oxf) (2011) 203(1):25969

However, the expression of GPx1 has been reported to be down-regulated in thyroid cancer [44], colorectal cancer [45, 46], and gastric cancer [47], whereas GPx1 has been demonstrated to play an oncogenic role in kidney cancer [48], pancreatic cancer [49], and laryngeal squamous cell carcinoma [50]